Abstract
A series of thiol containing derivatives was prepared. Several of these compounds were found to inhibit matrix metalloproteinases 1, 3, and 9 with selectivity towards 3 and 9. Compounds 15, 20, and 22 were administered to rats orally at 75 mumol/kg. Drug levels of compounds 20 and 22 in the plasma were found to exceed the IC50 values for MMP 3 and 9 four hours after administration.
MeSH terms
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Animals
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Dose-Response Relationship, Drug
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Drug Design
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Inhibitory Concentration 50
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Matrix Metalloproteinase Inhibitors
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Metalloendopeptidases / antagonists & inhibitors*
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Rats
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Sulfhydryl Compounds / administration & dosage
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Sulfhydryl Compounds / blood
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Sulfhydryl Compounds / chemical synthesis*
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Time Factors
Substances
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Matrix Metalloproteinase Inhibitors
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Sulfhydryl Compounds
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Metalloendopeptidases